Stereochemistry Enhances Potency, Efficacy, and Durability of <i>Malat1</i> Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species - Concepedia

Concepedia

Publication | Open Access

Stereochemistry Enhances Potency, Efficacy, and Durability of <i>Malat1</i> Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species

DOI Full Paper Access

30

Citations

16

References

2021

Year

Michael Byrne, Vinod Vathipadiekal, Luciano H. Apponi, Naoki Iwamoto, Kandasamy Pachamuthu, Kenneth Longo, Fangjun Liu, Richard Looby, Lauren Norwood, Anee Shah,

Translational Vision Science & Technology

Abstract

As novel therapeutics, stereopure oligonucleotides have the potential to enable infrequent administration and low-dose regimens for patients with genetic diseases of the eye.

References

	Year	Citations

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