Next-generation sequencing not superior to culture in periprosthetic joint infection diagnosis

Abstract

In our series, NGS did not provide superior sensitivity or specificity results compared to culture. PCR has little utility as a standalone test for PJI diagnosis with a sensitivity of only 18.4%. Currently, several laboratory tests for PJI diagnosis should be obtained along with the overall clinical picture to help guide decision-making for PJI treatment. Cite this article: <i>Bone Joint J</i> 2021;103-B(1):26-31.