Metal-free approach for hindered amide-bond formation with hypervalent iodine(<scp>iii</scp>) reagents: application to hindered peptide synthesis

Abstract

A new, bulky amide and peptide synthesis with hypervalent iodine(<sc>iii</sc>) reagent/pyridine–hydrogen fluoride complex under mild and metal-free conditions was developed by using α-amino esters with potential activating group (PAG) at the ester residue.