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Previous Dengue Infection and Mortality in Coronavirus Disease 2019 (COVID-19)

Odílson Marcos Silvestre, Letícia Roberta Martins Costa, Bianca V R Lopes, Mariana Ramos Barbosa, Kárenn Klycia Pereira Botelho, Kelvyn L C Albuquerque, Anna G S Souza, Lorran A Coelho, Anderson José de Oliveira, Cínthia B Barantini,

Clinical Infectious Diseases · 2020 · 36 citations · 5 references

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Concepts

Veterinary MedicineImmunologyInfectious DiseasesEpidemiologyImmunology Of Infectious DiseasesInfectious Disease EpidemiologyAcute Respiratory Distress SyndromeAntiviral ImmunityInfectious Disease Risk FactorsViral InfectionsViral PathogenesisCovid-19-associated Acute Respiratory Distress SyndromeImmunological ResponseSevere Acute Respiratory Syndrome

Abstract

We studied 2351 participants with coronavirus disease 2019; 1177 (50%) reported previous dengue infection. Those without previous dengue had a higher risk of death (hazard ratio: .44; 95% confidence interval: .22-.89; P = .023) in 60-day follow-up. These findings raise the possibility that dengue might induce immunological protection against severe acute respiratory syndrome coronavirus 2.