Decreased plasma rifapentine concentrations associated with <i>AADAC</i> single nucleotide polymorphism in adults with tuberculosis

Abstract

Rifapentine exposure in black participants varied with AADAC rs1803155 genotype and the G allele was more likely to be associated with below bactericidal target rifapentine exposure. Further pharmacogenomic study is needed to characterize the association of the AADAC rs1803155 with inadequate rifapentine exposure in different patient groups.