Multiple Endocrine Tumors Associated with Germline <i>MAX</i> Mutations: Multiple Endocrine Neoplasia Type 5?

Abstract

Germline MAX mutations are associated with PCs, ganglioneuromas, neuroblastomas, pituitary neuroendocrine tumors, and, possibly, parathyroid adenomas, as well as nonendocrine tumors of chondrosarcoma and lung adenocarcinoma, suggesting MAX is a novel multiple endocrine neoplasia gene.