Synthesis of (<i>E</i>)-Quinoxalinone Oximes through a Multicomponent Reaction under Mild Conditions

Abstract

Herein, a novel method for the gram-scale synthesis of (<i>E</i>)-quinoxalinone oximes through a multicomponent reaction under mild conditions is described. Such a transformation was performed under transition-metal-free conditions, affording (<i>E</i>)-oximes in a moderate-to-good yield through recrystallization. Our methodology demonstrates a successful combination of a Mannich-type reaction and radical coupling, providing a green and practical approach for the synthesis of potentially bioactive quinoxalinone-containing molecules.