M2 microglial small extracellular vesicles reduce glial scar formation <i>via</i> the miR-124/STAT3 pathway after ischemic stroke in mice

Abstract

Rationale: Glial scars present a major obstacle for neuronal regeneration after stroke. Thus, approaches to promote their degradation and inhibit their formation are beneficial for stroke recovery. The interaction of microglia and astrocytes is known to be involved in glial scar formation after stroke; however, how microglia affect glial scar formation remains unclear.