<i>BRCA1/2</i> pathogenic variants in triple-negative <i>versus</i> luminal-like breast cancers: genotype–phenotype correlation in a cohort of 531 patients

Abstract

Future studies examining the type and location of <i>BRCA1/2</i> PVs within different molecular subtypes are required to verify our hypothesis and could provide an interesting insight into the complex topic of genotype-phenotype correlations. Additionally, a more in-depth understanding of the potential correlations between <i>BRCA</i> PVs and clinical and phenotypic features of hereditary BC syndrome patients could be the key to develop better strategies of prevention and surveillance in <i>BRCA</i>-positive carriers without disease.