The Pharmacodynamic-Toxicodynamic Relationship of AUC and <i>C</i> _max in Vancomycin-Induced Kidney Injury in an Animal Model

Abstract

as the most predictive PK-TD driver for vancomycin-induced kidney injury (VIKI) (-5.28 versus -1.95). While PK-TD indices are often intercorrelated, maximal concentrations and fewer doses (for the same total daily amount) resulted in increased VIKI in our rat model.