Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study

Abstract

Lifelong exposure of rats to low-dose BPA at 25 and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>250</mml:mn><mml:mspace></mml:mspace><mml:mi>μ</mml:mi><mml:mi>g</mml:mi><mml:mo>/</mml:mo><mml:mi>kg</mml:mi></mml:mrow></mml:math> BW/d altered the estrous cycle and uterine pathology with similarity to EE2. The exposure also disrupted a unique low-dose BPA-gene signature with predictive value for survival outcomes in patients with endometrial cancer. https://doi.org/10.1289/EHP6875.