Chemical constituents of <i>Chaenomeles sinensis</i> twigs and their biological activity

Abstract

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (<b>1</b>), was isolated from the twigs of <i>Chaenomeles sinensis</i> together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate <b>1</b> was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.