Convergent Domino Cyclization: Oxidative [3+1+1] Annulation for One‐Pot Synthesis of 2‐Quinoline‐4,5‐diaryl‐oxazoles from Methyl Azaarenes, Benzoins and NH₄OAc

Abstract

Abstract An oxidative [3+1+1] convergent domino cyclization is disclosed. This protocol enables to get quinoline, quinoxaline, quinazolin‐4(3H)‐one and benzo[d]thiazole attached 2,4,5‐trisubstituted oxazoles from methyl azaarenes, benzoins, and NH 4 OAc in the presence of iodine and molecular sieves without any metal catalyst. The reaction features wide substrate scope, good functional group tolerance, mild reaction conditions, and easily available substrates.