A Stepwise Synthesis of Spiroindoline Compounds via Ring Opening of Aziridines and C−H Activation/Cyclization

Abstract

Abstract A type of 2,2‐disubstituted N‐sulfonylaziridines bearing OTBS groups and aryl groups at two different substitutions of the aziridine ring has been prepared. Based on them, a stepwise strategy involving ring opening of aziridines and C−H activation/cyclization has been developed for the general synthesis of spiroindoline pyrans and spiroindoline furans. magnified image