Harpertrioate A, an A,B,D-<i>seco</i>-Limonoid with Promising Biological Activity against Alzheimer’s Disease from Twigs of <i>Harrisonia perforata</i> (Blanco) Merr.

Abstract

Harpertrioate A (<b>1</b>), an A,B,D-<i>seco</i>-limonoid with a rearranged ring B incorporating exocyclic C-30, was isolated from the EtOAc extract of <i>Harrisonia perforata</i> twigs. Its structure, including absolute configurations, was determined on the basis of spectroscopic data and X-ray crystallography. This compound exhibited biological activities against Alzheimer's disease by reducing Aβ42 and Aβ40 production and shifting APP processing toward nonamyloidogenic pathway. The effect of <b>1</b> on the Aβ production was comparable to that of gemfibrozil.