JAMA Pediatrics · 2020 · 56 citations · 2 references
MedicineMaternal HealthMicrobiologyImmunizationMedical MicrobiologyPreterm BirthInfant Infectious DiseasesInfection In Preterm BirthNeonatal InfectionsPediatric Antibiotic TherapyPreterm Birth EpidemiologyRisk Factors For Preterm BirthEarly-life Microbiome DevelopmentInfections In PregnancyNeonatal Microbiome DevelopmentPreterm Infant Immunization
a single course of antibiotics and even beneficial effects to early antibiotics for infants born to mothers with possible dysbiosis. Postmenstrual age is the only significant driver identified so far for development of the preterm infant microbiome, independent of confounders such as delivery mode, breastfeeding, and antibiotics. 5 Initial colonization of the preterm infant cannot be assumed to be optimal. Infection may be a specific trigger of preterm birth, and alterations in the maternal microbiome have been associated with preterm delivery. 6 Although this study is limited by sample size, initial empirical
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