Path probability ratios for Langevin dynamics—Exact and approximate

Abstract

Path reweighting is a principally exact method to estimate dynamic properties from biased simulations-provided that the path probability ratio matches the stochastic integrator used in the simulation. Previously reported path probability ratios match the Euler-Maruyama scheme for overdamped Langevin dynamics. Since molecular dynamics simulations use Langevin dynamics rather than overdamped Langevin dynamics, this severely impedes the application of path reweighting methods. Here, we derive the path probability ratio M_L for Langevin dynamics propagated by a variant of the Langevin Leapfrog integrator. This new path probability ratio allows for exact reweighting of Langevin dynamics propagated by this integrator. We also show that a previously derived approximate path probability ratio M_approx differs from the exact M_L only by O(ξ⁴Δt⁴) and thus yields highly accurate dynamic reweighting results. (Δt is the integration time step, and ξ is the collision rate.) The results are tested, and the efficiency of path reweighting is explored using butane as an example.