Concepedia

Bladder cancer-derived interleukin-1 converts the vascular endothelium into a pro-inflammatory and pro-coagulatory surface

Axel John, Çagatay Güneş, Christian Bolenz, Sabine Vidal‐y‐Sy, Alexander T. Bauer, Stefan W. Schneider, Christian Gorzelanny

BMC Cancer · 2020 · 30 citations · 43 references

DOIFull text

Open access

Abstract

Our data indicate that IL-1 and IL-1ra were dysregulated in bladder cancer and could facilitate tumour dissemination through endothelial cell activation. Targeting the IL-1/IL-1ra axis might attenuate tumour-mediated inflammation and metastasis formation.

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