Increased circulating level of interleukin-6 and CD8+ T cell exhaustion are associated with progression of COVID-19

Abstract

Older age and higher levels of C-reactive protein, procalcitionin, interleukin-6, and lactate might predict COVID-19 progression. T lymphocyte, especially CD8⁺ cell-mediated immunity is critical in recovery of COVID-19. This study may help in predicting disease progression and designing immunotherapy for COVID-19.