<i>USP8</i> and <i>TP53</i> Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors

Abstract

Our data suggest that corticotroph tumors may be categorized into a USP8-mutated, genome-stable subtype versus a USP8-WT, genome-disrupted subtype, the latter of which has a TP53-mutated subtype with high level of chromosome instability. These findings could help identify high risk corticotroph tumors, namely those with widespread CNV, that may need closer monitoring and more aggressive treatment.