A Y(III)-based Metal–Organic Framework as a Carrier in Chemodynamic Therapy

Abstract

A biocompatible Y(III)-based metal-organic framework [Y₄(TATB)₂]·(DMF)_3.5·(H₂O) (ZJU-16, H₃TATB= 4,4',4''-(1,3,5-triazine-2,4,6-triyl) tribenzoic acid) was synthesized, and it was adopted to load Mn²⁺ for chemodynamic therapy. Meanwhile, ibuprofen sodium (IBUNa), an anti-inflammatory drug, was introduced to increase the amount of Mn²⁺ (about 5.66 wt %) due to the low loading capacity of Mn²⁺. Mn&IBUNa@ZJU-16 which was loaded by Mn²⁺ and IBUNa exhibited significant effects of chemodynamic therapy and excellent inhibition of the 4T1 tumor cell growth, implying its long-term prospects in chemodynamic therapy and its possibility in bimodal cancer therapy.