Concepedia

Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines

Melissa C. D’Amaral, Nick Jamkhou, Marc J. Adler

Green Chemistry · 2020 · 48 citations · 55 references

DOI

Concepts

Abstract

A highly practical method for the direct coupling of amines and unactivated carboxylic acids to form amides.

References

55

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Atul Bhardwaj, Jatinder Kaur, Melinda Wuest et al. · Nature Communications · 2017 · 7.6K citations · Full text

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A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives

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Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

Joshua R. Dunetz, Javier Magano, Gerald A. Weisenburger · Organic Process Research & Development · 2015 · 799 citations

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A robustness screen for the rapid assessment of chemical reactions

Karl D. Collins, Frank Glorius · Nature Chemistry · 2013 · 632 citations

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Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited

Marian C. Bryan, Peter J. Dunn, David A. Entwistle et al. · Green Chemistry · 2018 · 601 citations · Full text

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