PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR

Abstract

This study highlights a novel shared signalling cascade, requiring each of Gα_q/11 , Gα_12/13 and β-arrestin1/2 for PAR2-induced ovarian cancer cell migration and invasion. This mechanism controlling a cellular function is unusual in not being linked to a specific individual G protein or β-arrestin-mediated signalling pathway.