Pediatrics International · 2020 · 17 citations · 36 references
MedicineInfectious DiseasesPediatricsImmunopathologyPediatric Infectious DiseasesPediatric RheumatologyBacterial InfectionsInflammatory Disease PathologyInflammatory Skin DiseasesInflammatory Skin DisordersJuvenile Idiopathic ArthritisPediatric VasculitisChildhood-onset VasculitisFever And Rash SyndromesKawasaki Disease Skin ManifestationsLaboratory MarkersMultisystem Inflammatory SyndromeScalded Skin SyndromeSystemic VasculitisVasculitis Mimics
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects patients younger than 5 years. In the absence of an available, affordable diagnostic test, detailed clinical history and physical examination are still fundamental to make a diagnosis. METHODS: We present five representative cases with KD-like presentations: systemic onset juvenile idiopathic arthritis, mycoplasma-induced rash and mucositis, staphylococcal scalded skin syndrome, BCGosis, and the recently described multisystemic inflammatory syndrome in children (MIS-C) associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) virus. RESULTS: Rash, fever, and laboratory markers of inflammation can be present in several childhood diseases that may mimic KD. CONCLUSION: The term 'Kawasaki syndrome' instead of 'Kawasaki disease' may be more appropriate. Physicians should consider an alternative diagnosis that may mimic KD, particularly considering MIS-C during the present pandemic, as an aggressive diagnostic and therapeutic approach is needed.
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