<p>Functional Measurement of CYP2C9 and CYP3A4 Allelic Polymorphism on Sildenafil Metabolism</p>

Abstract

These findings were the first evaluation of all these infrequent <i>CYP2C9</i> and <i>CYP3A4</i> alleles for sildenafil metabolism; when treating people who carry these CYP2C9 and CYP3A4 variants, there should be more focus on the relation of dose intensity, side effects and therapeutic efficacy when administering sildenafil. The study will provide fundamental data on effect of <i>CYP2C9</i> and <i>CYP3A4</i> allelic variation on sildenafil metabolism for further clinical research.