<scp>L</scp>‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA₁

Abstract

Our study demonstrates that neurogenesis in the two main neurogenic niches in the brain is regulated differently: Neurogenesis in both niches was induced by exercise, but only in the ventricular-subventricular zone was neurogenesis induced by lactate through HCA₁ activation. This opens for a role of HCA₁ in the physiological control of neurogenesis, and potentially in counteracting age-related cognitive decline.