Concepedia

Publication | Open Access

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy

DOIFull Paper Access

137

Citations

69

References

2020

Year

Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou‐Solomidou, Shinichi Oka,
Circulation Research

Abstract

Diabetes-mediated activation of cardiomyocyte FOXO1 increases KLF5 expression, which stimulates NOX4 expression, ceramide accumulation, and causes DbCM.

References

YearCitations

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