Metabolic brain changes across different levels of cognitive impairment in ALS: a¹⁸F-FDG-PET study

Abstract

These data support the concept that patients with cognitive impairment have a more widespread neurodegenerative process compared with patients with a pure motor disease: the more severe the cognitive impairment, the more diffuse the metabolic changes. Otherwise, metabolic changes related to pure behavioural impairment need further characterisation.