Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study

Abstract

WMH were strongly associated with concurrent and past elevated BP with the population burden of severe WMH greatest for SBP. However, before the age of 50, DBP was more strongly associated with WMH. Long-term prevention of WMH may require control of even mildly elevated midlife DBP.