Surgical Treatment of Medication-Related Osteonecrosis of the Jaw: A Retrospective Study

Abstract

The purpose of this study was to confirm the success rate of surgical treatment of medication-related osteonecrosis of the jaw (MRONJ) in patients at a single institution (Association of Oral and Maxillofacial Surgery (AAOMS) stages 1, 2, or 3), and to identify the factors that influence treatment outcomes. As a result of analyzing the outcomes of treatment, surgical "success" was achieved in 93.97% (109) of cases, and "failure" was observed at 6.03% (7) cases. Analysis of patient factors that potentially affect treatment outcomes showed that zoledronate dose (<i>p</i> = 0.005) and the IV (intravenous) injection of drugs (<i>p</i> = 0.044) had significant negative impacts.