Antimicrobial and Anticancer Activities of Actinomycetes Isolated from Egyptian Soils

Abstract

Actinomycetes have got considerable attention worldwide due to the production of many useful bioactive metabolites. In the present study, the antimicrobial potential of novel Actinomycetes has been evaluated by the initial screening of seven rhizosphere samples in Egypt. The primary and secondary screening were performed against Bacillus cereus (ATCC33018), and E.coli O157 (ATCC93111) as model strains of Gram positive and Gram negative species, respectively. GC-MS analysis of most active Actinomycetes extracted secondary metabolites was studied. The major compounds identified by GC-MS analysis include 2, 4-di-tert-butylphenol, 3-chloropropionic acid, heptadecyl ester, 1,2-benzenedicarboxylic acid,3-nitro, benzenepropanoic acid,3,5-bis(1,1 dimethylethyl)-4-hydroxy-, octadecyl ester, 1-monopalmitin,2TMS derivative, 1-docosene, 1-nonadecene and 1-nonacosene.