Role of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Mean Platelet Volume in Egyptian Patients with Psoriasis Vulgaris.

Abstract

Psoriasis vulgaris (PsV) is common, incurable, pro-inflammatory systemic disease with waving course that impacts the life quality. This justifies the need for discovering simple biomarkers with key roles in monitoring systemic inflammation and assessing the disease severity. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been suggested as markers of inflammation. We aimed to investigate the role of NLR, PLR and MPV as biomarkers for PsV disease and to examine their possible association with disease severity assessed by Psoriasis Area and Severity Index (PASI score) in Egyptian psoriatic patients. This case control study included 36 PsV patients and 36 healthy controls. Hematological parameters were assessed by automated KX21N cell counters. Significant increase was detected in NLR (P < 0.001) and PLR (P < 0.001) in PsV patients when compared to controls. PASI score positively correlated with PLR (r=0.405; P=0.014) and negatively correlated with MPV (r= -0.471; P=0.004). NLR positively correlated with disease duration/ years (r=0.414; P=0.012). ROC curves data output showed that NLR at cut off of 1.66 yielded a specificity of (94.4%) and sensitivity of (61.1%) (P < 0,001) to differentiate PsV patients from healthy individuals and, PLR at cut-off of 110.6 yielded a higher sensitivity of (77.81%) with specificity of (86.1%) (P < 0.001). We concluded that NLR and PLR can serve as biomarkers for systemic inflammation in PsV disease. Increased NLR is more influenced by disease duration than disease severity. PLR and MPV can be applied to monitor psoriasis vulgaris severity and follow up of patients.