Concepedia

Exosomal miR-590-3p derived from cancer-associated fibroblasts confers radioresistance in colorectal cancer

Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu

Molecular Therapy — Nucleic Acids · 2020 · 101 citations · 34 references

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Concepts

Abstract

experimental results confirmed that CAF-derived exosomal miR-590-3p stimulated tumor growth in mice following radiotherapy. Our results demonstrate that miR-590-3p delivery via exosomes derived from CAFs enhances radioresistance in CRC through the positive regulation of the CLCA4-dependent PI3K/Akt signaling pathway.

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