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Intrauterine Transmission of SARS-CoV-2

Emanuele Therezinha Schueda Stonoga, Laura Lanzoni, Patrícia Zadorosnei Rebutini, André Luiz Permegiani de Oliveira, Jullie Anne Chiste, Cyllian Arias Fugaça, Daniele Margarita Marani Prá, Ana Paula Percicote, Andrea Maciel de Oliveira Rossoni, Meri Bordignon Nogueira,

Emerging infectious diseases · 2020 · 47 citations · 9 references

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Concepts

Life SciencesInfectious DiseasesObstetricsImmunopathologyMolecular VirologyVirologyPlacental ImmunologyPlacental PathologyPlacental PhysiologyViral InfectionsViral PathologyChronic Histiocytic IntervillositisHistiocytic Inflammatory LesionsIntrauterine Fetal DeathLymphocytic InfiltratesLymphocytic InflammationPlacental Vascular MalperfusionSars-cov-2 InfectionSevere Acute Respiratory Syndrome

Abstract

We documented fetal death associated with intrauterine transmission of severe acute respiratory syndrome coronavirus 2. We found chronic histiocytic intervillositis, maternal and fetal vascular malperfusion, microglial hyperplasia, and lymphocytic infiltrate in muscle in the placenta and fetal tissue. Placenta and umbilical cord blood tested positive for the virus by PCR, confirming transplacental transmission.