Proceedings of the National Academy of Sciences · 2020 · 30 citations · 57 references
Life SciencesCell BiologyImmunologyCell SignalingCellular ImmunologyInnate ImmunityDendritic Cell BiologyDendritic DevelopmentImmune Cell SignalingInnate Immune Cell DevelopmentInnate Immune Signaling PathwaysNotch SignalingConventional Dendritic Cell DifferentiationDendritic Cell OntogenyDendritic Cell Pattern Recognition Receptor SignalingDendritic Cell SignalingNotch Receptor SignalingNotch Signaling ActivationTerminal Differentiation Maintenance
Significance Dendritic cells (DC) play a crucial role in the immune system by bridging innate and adaptive immunity. In the spleen, a specific subset of DCs accumulates around the blood-filtering marginal zone to capture particulate antigens such as red blood cells. We show here that these specialized DCs develop in response to NOTCH2 instruction that is regulated by a poorly studied kinase, called Thousand and One Kinase 3 (TAOK3). This kinase controls DC development in a cell-intrinsic manner, rendering cells receptive to NOTCH2 signaling. Interfering with this kinase opens up ways to manipulate a specific subset of DCs.
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