Aging · 2020 · 37 citations · 33 references
MedicineImmunologyOncologyImmunotherapyMolecular OncologyTumor MicroenvironmentCancer GenomicsEndometrial CancerImmune Cell InfiltrationImmuno-oncology BiomarkersTumor Immune MicroenvironmentTumor ImmunopathologyEndometrial Immune BiomarkersEndometrioid NeoplasmsGenetic Prognostic MarkersImmune Cell Infiltration DensityImmune Infiltration BiomarkersImmune Microenvironment PrognosisImmunohistochemical BiomarkersPik3ca Mutations
mutational status. A search for LCK-related modules returned seven independent genetic predictors of survival in patients with endometrial cancer. The TIMER algorithm showed that the expression of these seven genes was positively correlated with the infiltration levels of six types of immune cells. The diagnostic value of these markers was validated using real-time quantitative PCR and immunohistochemical methods. Our results identified CD74, HLA-DRB5, CD52, HLA-DPB1 and HLA-DRB1 as possible valuable genetic markers for the diagnosis and prognosis of endometrial cancer and provided a theoretical basis for immunotherapy targets for its clinical treatment.
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Cancer treatment and survivorship statistics, 2019
Kimberly D. Miller, Letícia Nogueira, Angela B. Mariotto et al. · CA A Cancer Journal for Clinicians · 2019 · 4.4K citations · Full text
Proteogenomic Characterization of Endometrial Carcinoma
Yongchao Dou, Emily Kawaler, Daniel Cui Zhou et al. · Cell · 2020 · 534 citations · Full text