Novel 3,4-dihydroquinolin-2(1H)-one derivatives as dual inhibitor targeting AKR1B1/ROS for treatment of diabetic complications: Design, synthesis and biological evaluation

Biochemistry and molecular cell biology of diabetic complications

Michael Brownlee · Nature · 2001 · 9K citations

Life Sciences, Biochemistry, Cell Biology +14

Design and Synthesis of Potent and Multifunctional Aldose Reductase Inhibitors Based on Quinoxalinones

Xiangyu Qin, Xin Hao, Hui Han et al. · Journal of Medicinal Chemistry · 2015 · 244 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

Miguel A. Lanaspa, Takuji Ishimoto, Nanxing Li et al. · Nature Communications · 2013 · 241 citations · Full text

Life Sciences, Biochemistry, Physiology +14

Targeting Aldose Reductase for the Treatment of Diabetes Complications and Inflammatory Diseases: New Insights and Future Directions

Rosanna Maccari, Rosaria Ottanà · Journal of Medicinal Chemistry · 2014 · 187 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Pyrido[1,2-<i>a</i>]pyrimidin-4-one Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors Exhibiting Antioxidant Activity

Concettina La Motta, Stefania Sartini, Laura Mugnaini et al. · Journal of Medicinal Chemistry · 2007 · 151 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13