<p>Enhanced Osseointegration of Titanium Implants by Surface Modification with Silicon-doped Titania Nanotubes</p>

Abstract

The modification of Si-TiO₂-NTs on the Ti substrate could generate a nanostructured and hydrophilic surface, which can promote cell growth. Moreover, the existence of the TiO₂ nanotubes and Si element also can improve the in vitro osteogenic differentiation of MC3T3-E1 cells and early bone formation around the implanted screws. Together, findings from this study show that surface modification of Ti implants with Si-TiO₂ nanotubes could enhance early osseointegration and therefore has the potential for clinical applications.