Rh(III)‐Catalyzed C2‐Alkylation of Indoles with Maleimides at Low Catalyst Loadings

Abstract

Abstract The Rh(III)‐catalyzed C2‐alkylation of indoles with maleimides is disclosed under additive‐free conditions by employing pyridine as a removable directing group. This protocol features low catalyst loadings, simple reaction conditions and good functional group tolerance. In addition to various indoles and maleimides, arenes, pyrroles, maleates as well as ethyl acrylates are applicable substrates.