Concepedia

HDAC1-mediated deacetylation of HIF1α prevents atherosclerosis progression by promoting miR-224-3p-mediated inhibition of FOSL2

Hao Wang, Kazuo Sugimoto, Hao Lu, Wanyong Yang, Ji-Yue Liu, Hongyu Yang, Yuebo Song, Tianyu Zou, Si Shen

Molecular Therapy — Nucleic Acids · 2020 · 29 citations · 51 references

DOIFull text

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Concepts

Abstract

. In summary, HDAC1 overexpression may enhance the anti-atherosclerotic and endothelial-protective effects of miR-224-3p-mediated inhibition of FOSL2 by deacetylating HIF1α, underscoring a novel therapeutic insight against experimental atherosclerosis.

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