Concepedia

The mammalian circadian pacemaker regulates wakefulness via CRF neurons in the paraventricular nucleus of the hypothalamus

Daisuke Ono, Yasutaka Mukai, Chi Jung Hung, Srikanta Chowdhury, Takashi Sugiyama, Akihiro Yamanaka

Science Advances · 2020 · 103 citations · 55 references

DOIFull text

Open access

Concepts

Abstract

imaging revealed that neuronal activity of CRF neurons was negatively regulated by GABAergic neurons in the SCN. Our findings provide notable insights into circadian regulation of sleep/wakefulness in mammals.

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