<i>Lactobacillus lactis</i> CKDB001 ameliorate progression of nonalcoholic fatty liver disease through of gut microbiome: addendum

Abstract

According to our recent study (N.Y. LEE et al. Gut Microbes 2020; 11:882-99.)¹, we reported that <i>Lactobacillus</i> and <i>Pediococcus</i> ameliorate progression of nonalcoholic fatty liver disease through modulation of the gut microbiome. According on the analysis method (Previous: 16s rRNA sequencing and Recent: whole gene sequencing), the probiotics named <i>Lactobacillus bulgaricus</i> that we used in the experiment was identified as <i>Lactobacillus delbrueckii</i> subsp. <i>bulgaricus</i> through 16s rRNA sequencing analysis. Recently, we performed a clearer analysis with whole gene sequencing to proceed with the clinical trial, it was identified as <i>Lactobacillus delbrueckii</i> subsp. <i>lactis</i> by whole gene sequencing. Therefore, we inform that the subspecies have been changed to <i>lactis</i> through WGS. Read <i>L. bulgaricus</i> in the previous paper as <i>L. lactis</i>. In this addendum, the results of the change to <i>L. lactis</i> are summarized, and descriptions have been added to Materials & methods and Discussion.