Ganoweberianones A and B, Antimalarial Lanostane Dimers from Cultivated Fruiting Bodies of the Basidiomycete <i>Ganoderma weberianum</i>

Abstract

Two lanostane dimers, ganoweberianones A (<b>1</b>) and B (<b>2</b>), together with seven previously undescribed lanostanes, ganoweberianic acids A-G (<b>3</b>-<b>9</b>), and three known compounds (<b>10</b>-<b>12</b>), were isolated from the artificially cultivated fruiting bodies of the basidiomycete <i>Ganoderma weberianum</i>. Ganoweberianone A (<b>1</b>) exhibited significant antimalarial activity against <i>Plasmodium falciparum</i> K1 (multidrug-resistant strain) with an IC₅₀ value of 0.050 μM. A method for semisynthesis of <b>1</b> by condensation of the corresponding lanostane monomers and acid-catalyzed intramolecular transesterification was demonstrated.