Concepedia

CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation

Shan Cui, Chenhui Wang, Weizhi Bai, Jiao Li, Yue Pan, Xiaoyong Huang, Han Yang, Zeqing Feng, Qun Xiang, Lixin Zheng,

Science Advances · 2020 · 43 citations · 31 references

DOIFull text

Open access

Concepts

Abstract

in macrophages. Therefore, the counterbalancing role of CD1d1 in macrophages appears to determine severity of DSS-mediated colitis in mice. These findings propose new intervention strategies for treating IBD and other inflammatory disorders.

References

31

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz et al. · The Journal of Immunology · 2009 · 2.9K citations · Full text

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A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice

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IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

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The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

Hasan Zaki, Kelli L. Boyd, Peter Vogel et al. · Immunity · 2010 · 976 citations · Full text

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Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation

Atsushi Mizoguchi, Emiko Mizoguchi, Hidetoshi Takedatsu et al. · Immunity · 2002 · 955 citations · Full text

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