Palladium(<scp>ii</scp>) complexes bearing 1-iminothiolate-3,5-dimethylpyrazoles: synthesis, cytotoxicity, DNA binding and enzymatic inhibition studies

Abstract

This work describes the enzymatic inhibitory activity of four novel Pd(<sc>ii</sc>) complexes towards topoisomerase IIα and cathepsins B and L.<italic>In silico</italic>studies agree well with the enhanced<italic>in vitro</italic>cathepsin B inhibition induced by compound<bold>4</bold>(58% at 10 μM).