<i>PLEK2</i> Gene Upregulation Might Independently Predict Shorter Progression-Free Survival in Lung Adenocarcinoma

Abstract

Increased <i>PLEK2</i> expression might be a specific prognostic biomarker of poor PFS in LUAD patients. Its expression had significant positive correlations with invasion, cell cycle, DNA damage, and DNA repair of LUAD cells at the single-cell level. Promoter hypomethylation might be a potential mechanism leading to its upregulation.