The effect of ageing and cerebral serotonin deficit on the activity of cytochrome P450 2D (CYP2D) in the brain and liver of male rats

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

Ai‐Ming Yu, Jeffrey R. Idle, Linda G. Byrd et al. · PubMed · 2003 · 160 citations

Medicine, Neuroscience, Pharmacology +17

Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain

Isabel Siegle, Péter Fritz, Klaus Eckhardt et al. · Pharmacogenetics · 2001 · 147 citations

Life Sciences, Neurobiology, Neuroscience +16

The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients

Amandeep Mann, Sharon Miksys, Andrea Gaedigk et al. · Neurobiology of Aging · 2011 · 91 citations

Life Sciences, Neuroscience, Pharmacology +13

Hepatic and Central Nervous System Cytochrome P450 Are Down-Regulated during Lipopolysaccharide-Evoked Localized Inflammation in Brain

Kenneth W. Renton, T. Nicholson · Journal of Pharmacology and Experimental Therapeutics · 2000 · 72 citations

Life Sciences, Neuroscience, Pharmacology +15

The ability of cytochrome P450 2D isoforms to synthesize dopamine in the brain: An in vitro study

Ewa Bromek, Anna Haduch, Władysława A. Daniel · European Journal of Pharmacology · 2009 · 69 citations

Life Sciences, Neuroscience, Pharmacology +13