Radioiodination and biological evaluation of irbesartan as a tracer for cardiac imaging

Abstract

Abstract Irbesartan was labeled using 125 I or 131 I with N-bromosuccinimide (NBS) as an oxidizing agent. A lot of operators such as, quantity of substrate, the quantity of oxidizing agent, reaction temperature, reaction time, and pH of reaction medium were studied to optimize high radiochemical yield of [ 125 I]IodoIrbesartan ([ 125 I]Irb.). The preclinical evaluation of IodoIrbesartan in experimental mice indicated high accumulation in target organ of heart with a high heart/blood ratio of 12.85 at 30 min post-injection. This study indicates the suitability of [ 125 I]IodoIrbesartan ([ 125 I]Irb.) for cardiac imaging.