A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity

Abstract

At baseline, microbial composition was associated with fiber and protein intake. Subjects on the HPD showed a significant increase in microbial diversity as measured by the Shannon index compared to those on the NPD. The HPD was also associated with significant differences in microbial composition after treatment compared to the NPD. Both diets induced taxonomic shifts compared to baseline, including enrichment of <i>Akkermansia spp.</i> and <i>Bifidobacterium spp.</i> and depletion of <i>Prevotella spp.</i> Conclusion: These findings provide evidence that weight loss diets alter the gut microbiome in obesity and suggest differential effects of HPDs compared to NPDs which may influence the clinical response to HPD.