Clinical Nuclear Medicine · 2020 · 15 citations · 9 references
MedicineNuclear MedicineRadiologyMetastasisMolecular ImagingOncologic Nuclear MedicineBrain MetastasesBrain MetastasisBrain TumorsMalignant NeoplasmsNeuro-oncology ImagingTumor Receptor ImagingDiagnosis Of Brain MetastasesMetastatic Brain Tumor RecurrenceNeovascularizationProstate-specific Membrane Antigen PetProstate-specific Membrane Antigen Positron Emission TomographyTriple-negative Breast Cancer ImagingTumor Antigen HeterogeneityTumor Neovascularization
ABSTRACT: Triple negative breast cancer (TNBC) is characterized by poor prognosis and limited response to standard treatments. Although 18F-FDG PET/CT is frequently used in staging and restaging, in some cases, it may be insufficient considering tumor heterogeneity. Prostate-specific membrane antigen (PSMA) has been reported to be overexpressed in many types of cancer due to tumor-associated neovascularization. 68Ga-PSMA-11 PET/CT can be used to demonstrate radionuclide therapy option as well as detection of primary tumor and recurrence in TNBC. We present a 47-year-old woman with TNBC having recurrent brain metastasis with avid PSMA receptor activity versus low FDG uptake.
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Diagnostic Value of 68Ga PSMA-11 PET/CT Imaging of Brain Tumors—Preliminary Analysis
Arun Sasikumar, Ajith Joy, M. R. A. Pillai et al. · Clinical Nuclear Medicine · 2016 · 132 citations